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KMID : 1101320130450040131
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Korean Journal of Clinical Laboratory Science
2013 Volume.45 No. 4 p.131 ~ p.138
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The Relative Factors to Insulin Resistance and b Cell Function Determined by Homeostasis Model Assessment in Nondiabetic Adults
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Kwon Se-Young
Na Young-Ak
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Abstract
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Insulin resistance and pancreatic beta cell dysfunction have been established as being related to the diabetes. Lately, what is emphasizing is that those have been shown as something related to the metabolic syndrome and cardiovascular disease. Homeostasis model assessment (HOMA), simple index is calculated on blood levels of fasting glucose and insulin. And HOMA has been widely validated and applied for insulin resistance and pancreatic beta cell dysfunction. We also assessed the factors relative to insulin resistance and β cell function determined by HOMA. The data from the 2010 Korean National Health and Nutrition Examination Survey were used. Analysis was done for 3,465 nondiabetic subjects (male 1,357, female 2,108). At baseline, anthropometric measurements were done and fasting glucose, insulin, lipid (Total cholesterol, HDL cholesterol, LDL cholesterol and Triglycerides) profiles were measured. HOMA-insulin resistance (HOMA-IR) and beta cell function (HOMA β-cell) were calculated from fasting glucose and insulin levels. In male, the value of HOMA-IR and HOMA β-cell was the highest among 30's and decreased as the age increased. In female, the value of HOMA-IR increased with age, while HOMA β-cell decreased. High HOMA-IR and low HOMA β-cell were associated with the highest value of fasting glucose and systolic blood pressure. Low HOMA-IR and high HOMA β-cell showed the lowest concentration of fasting glucose and the highest concentration of HDL cholesterol. High HOMA-IR and high HOMA β-cell were connected with BMI, Total cholesterol, LDL cholesterol, and Triglycerides. There was a negative correlation between HOMA β-cell and age. The correlation coefficients of HOMA-IR and HOMA β-cell showed the highest value among weight, BMI and WC.
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KEYWORD
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Diabetes mellitus, HOMA-IR, HOMA β-cell
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